Zebrzydowski's Rebellion, or the Sandomierz Rebellion, is a rokosz (semi-legal rebellion) in the Polish-Lithuanian Commonwealth against King Sigismund III Vasa.

The rokosz, formed on August 5, 1606 by Mikołaj Zebrzydowski, Jan Szczęsny Herburt, Stanisław Stadnicki, Aleksander Józef Lisowski and Janusz Radziwiłł in Stężyca and Lublin, is caused by the growing dissatisfaction with the King among the nobility (szlachta), who disapprove of the King's efforts to limit the power of the nobles (his attempts to weaken the Sejm, the Polish parliament) and to introduce a hereditary monarchy in place of the elective one).

The rebellion (1606-08) ends in the defeat of the rebels.

Despite its failure to overthrow the King, it firmly establishes the dominance of the szlachta over the monarch in the Polish-Lithuanian political system.