The Roman-Syrian War (192 BCE - 188 BCE), also known as War of Antiochos or Syrian War, is a military conflict between two coalitions led by the Roman Republic and the Seleucid Empire under Antiochus the Great.

The fighting takes place in Greece, the Aegean Sea and Asia Minor.The war is the consequence of a "cold war" between both powers, which had started already in 196 BCE.

In this period Romans and Seleucids had tried to settle spheres of influence by making alliances with the Greek minor powers.The fighting ends with a clear victory of the Romans.

In the Treaty of Apamea, the Seleucids are forced to give up Asia Minor, which falls to Roman allies.

As a main result of the war the Roman Empire gains the hegemony over Greece and becomes the only remaining major power around the Mediterranean Sea.