The second major uprising by the Prussians, known historiographically as "The Great Prussian Uprising", is prompted by the 1260 Battle of Durbe, the largest defeat suffered by the Teutonic Knights in the thirteenth century.

This uprising is the longest, largest, and most threatening to the Teutonic Knights, who again are reduced to five of their strongest castles.

Reinforcements for the Knights are slow to arrive, despite repeated encouragements from Pope Urban IV, and the position of the Knights looks set to worsen.

Luckily for the Teutons, the Prussians lack unity and a common strategy and reinforcements finally reach Prussia in around 1265.

One by one, Prussian clans surrender and the uprising is ended in 1274.