The Persia-Portugal war is the war between the Portuguese Empire and its vassal Kingdom of Ormus on one side, and the Safavid Empire with the help of the English between 1507 and 1622.

During this era, Portugal establishes its rule for about eighty years in Ormuz and Bahrain.

They capture some other islands and ports such as Qeshm and Bandar Abbas for few years.

Finally the Safavid king, Abbas I, reconquers these territories and drives the Portuguese from the Persian Gulf.In September 1507, the Portuguese Afonso de Albuquerque lands on the Island of Hormuz.

Portugal occupies Ormuz from 1515 to 1622.

As a vassal of the Portuguese state, the Kingdom of Ormus jointly participates in the 1521 invasion of Bahrain that ends Jabrid rule of the Persian Gulf archipelago.After the Portuguese make several abortive attempts to seize control of Basra, Abbas conquers the kingdom with the help of the British East India Company, and expels the Portuguese from the rest of the Persian Gulf, with the exception of Muscat.

The Portuguese return to the Persian Gulf in the following year as allies of Afrasiyab, the Pasha of Basra, against the Persians.