The Muscovite-Lithuanian Wars, also known as the Russo-Lithuanian Wars, or just either Muscovite Wars or Lithuanian Wars, are a series of wars between the Grand Duchy of Lithuania, allied with the Kingdom of Poland, and Grand Duchy of Moscow.

After several defeats at the hands of Ivan III and Vasily III, the Lithuanians are increasingly reliant on Polish aid, which eventually becomes an important factor in the creation of the Polish-Lithuanian Commonwealth.

In the first series of wars in the fifteenth century the Lithuanians gain control of a lot of Rus' territories, from Kiev to Mozhaisk, but over the course of the series of wars, particularly in the sixteenth century, the Russians are able to expand their domain westwards, taking control of much of the lands that were once part of Kievan Rus.