The Macedonian and Seleucid wars are a series of conflicts fought by Rome during and after the second Punic war, in the eastern Mediterranean, the Adriatic, and the Aegean.

Along with the Punic wars, they will result in Roman control or influence over the entire Mediterranean basin.The First Macedonian War (214 BCE - 205 BCE) is fought by Rome, allied (after 211 BCE) with the Aetolian League and Attalus I of Pergamon, against Philip V of Macedon, contemporaneously with the Second Punic War against Carthage.

There are no decisive engagements, and the war ends in a stalemate.During the war, Macedon attempts to gain control over parts of Illyria and Greece, but without success.

It is commonly thought that these skirmishes in the east prevented Macedon from aiding the Carthaginian general Hannibal in the war with Rome.

The "Peace of Phoenice", a treaty drawn up at Phoenice, in 205 BC, formally ends the war.