The Loaísa expedition is a sixteenth-century voyage of discovery to the Pacific Ocean, commanded by Garcia Jofre de Loaísa (1490 – July 20, 1526) and ordered by King Charles I of Spain to colonize the Spice Islands in the East Indies.

After an uneventful start the expedition is scattered by bad weather near Cape Horn, leading to the ultimate loss of six of its seven ships.

The remaining vessel reaches its destination, but the survivors are too few to establish an effective colony and ultimately choose to return to Spain.