The Battle of Fort Duquesne is a British assault on the eponymous French fort (later the site of Pittsburgh) that is repulsed with heavy losses on September 14, 1758, during the French and Indian War.

The attack on Fort Duquesne is part of a large-scale British expedition with six thousand troops led by General John Forbes to drive the French out of the contested Ohio Country (the upper Ohio River Valley) and clear the way for an invasion of Canada.

Forbes orders Major James Grant of the 1st Highland Regiment to reconnoiter the area with eight hundred and fifty men.

When Grant proceeds to attack the French position, his force is out maneuevred, surrounded, and largely destroyed by the French and their native allies led by François-Marie Le Marchand de Lignery.

Major Grant is taken prisoner and the British survivors retreat fitfully to Fort Ligonier.

After repulsing this advance party the French, deserted by some of their native allies and vastly outnumbered by the approaching Forbes, blow up their magazines and burn Fort Duquesne.

In November the French withdraw from the Ohio Valley and British colonists erect Fort Pitt on the site.