The Campaign against Dong Zhuo in 190 is initiated by a coalition of regional officials hoping to end Chancellor Dong Zhuo's influence in the ailing Han court in China.

With Yuan Shao as their leader, dissenting officials revolt against Dong, claiming that Dong is set on usurping the throne and has effectively kidnapped the young Emperor Xian.

This campaign causes Dong to move the entire imperial court from Luoyang to Chang'an, and is a prelude to the end of Han Dynasty and, subsequently, the Three Kingdoms period.In the Chinese literary classic Romance of the Three Kingdoms, this campaign is memorable for at least two famous incidents: one where the previously unknown Guan Yu slays the established warrior Hua Xiong; the other where Liu Bei, Guan Yu, and Zhang Fei battle Lü Bu — the mightiest warrior in the novel.

The two scenes are often reenacted in the Chinese opera, along with other famous scenes from the novel.