The Comanche–Mexico Wars are conflicts from 1821 to 1870 that consists of large-scale raids into northern Mexico by Comanches and their Kiowa allies which leave thousands of people dead.

The Comanche raids are sparked by the declining military capability of Mexico in the turbulent years after it gains independence in 1821, plus a large and growing market in the United States for stolen Mexican horses and cattle.By the time the United States army invades northern Mexico in 1846 during the Mexican-American War, the region is devastated.

Comanche raids into Mexico continue until 1870.

The Comanche are finally defeated by the U.S. in 1875 and forced onto a reservation.