The second cholera pandemic (1826–1837), also known as the Asiatic cholera pandemic, is a cholera pandemic that reaches from India across western Asia to Europe, Great Britain, and the Americas, as well as east to China and Japan.

Cholera cause more deaths, more quickly, than any other epidemic disease in the ninetenth century

The medical community now believes cholera to be exclusively a human disease, spread through many means of travel during at the time, and spread through warm fecal-contaminated river waters and contaminated foods.

During the second pandemic, the scientific community varies in its beliefs about the causes of cholera.