The Battle of Callinicum takes place Easter day, 19 April 531, between the armies of the Eastern Roman Empire under Belisarius and the Sassanid Persians under Azarethes.

After a defeat at the Battle of Dara, the Sassanids move to invade Syria in an attempt to turn the tide of the war.

Belisarius' rapid response fois the plan, and his troops push the Persians out of Syria through skillful maneuvering before forcing a battle.