The Siege of Caesarea takes place when the Sassanids under Shapur I besiege the Roman city of Antioch in 260 after winning over the Romans in the Battle of Edessa.

Caesarea during this time has a large population (about 400,000 inhabitants).

The Sassanids cannot take the city so they take a Roman as captive and torture him until he reveals a special way from which the Sassanids could take.

The Sassanids raid Caesarea during the night and kill every Roman soldier; however, the Roman general Demosthenes manages to escape during the raid.