The Battle of Barbalissos is fought between the Sassanid Persians and Romans at Barbalissos.

Shapur I uses Roman incursions into Armenia as pretext and resume hostilities with the Romans.

The Sassanids attack a Roman force at Barbalissos and the Roman army is defeated.

The defeat of this large Roman force leaves the Roman east open to attack and leads to the eventual capture of Antioch and Dura Europos three years later.

This battle is only known through Shapur's inscription at Naqš-e Rostam .