Tokugawa Ieyoshi (June 22, 1793–July 27, 1853; r.1837–1853) is the 12th shogun of the Tokugawa shogunate of Japan.

He is the second son of the 11th shogun, Tokugawa Ienari, and appointd Mizuno Tadakuni to conduct the Tenpo reform.

Shortly after the arrival of U.S. Commodore Matthew Perry, in 1853, whose purpose is to negotiate a treaty allowing American trade with Japan, Tokugawa Ieyoshi died, and is succeeded by his third son Tokugawa Iesada.

The following year, the Tokugawa shogunate is forced to accept the American demands after signing the Convention of Kanagawa.