Tigranes III is succeeded in 8 BCE by his son Tigranes IV and daughter from a different mother, Erato.

The reign of Tigranes IV coincides with the rise of anti-Roman sentiments within Armenian Kingdom.

The Roman Empire apparently did not approve Tigranes IV on the Armenian throne due to the strengthening of Parthia's influence the and pro-Parthian camp in Armenia.

As another major regional power, the Parthian Empire is a strong competitor with Rome over the expansion of imperial influence in the Armenian Kingdom.

Tigranes IV returns to power in Armenia in 2 BCE, likely with the help of the Parthians, but is killed the following year during a war against one of the Caucasian tribes.