Colonel Thomas Handasyd Perkins, or T. H. Perkins (December 15, 1764 – January 11, 1854) is a wealthy Boston merchant and an archetypical Boston Brahmin.

Starting with bequests from his grandfather and father-in-law, he amasses a huge fortune.

As a young man he is a slave trader in Haiti, a Maritime Fur Trader, trading furs from the American Northwest to China, and then a major smuggler of Turkish opium into China.