Theophano is a Byzantine empress.

She was the daughter-in-law of Constantine VII; wife of Romanos II; wife of Nikephoros II Phokas; lover of John I Tzimiskes; the mother of Basil II, Constantine VIII and the princess Anna Porphyrogenita, who later marries Kievan prince Vladimir.

Theophano plays an important role in 10th century Byzantine history.

She serves as Regent during the minority of her sons.