Sokollu Mehmed Pasha (Serbian: Mehmed-paša Sokolović,) (born as Bajica or Bajo Nenadić) 1506, Sokolovići, Bosnia - died 1579, Constantinople, Ottoman Empire) is a prominent 16th-century Ottoman statesman.

Mehmed was taken away at an early age as part of the devshirmeh system of Ottoman collection of young boys to be raised to serve as a janissary.

He rises through the ranks of the Ottoman imperial system, eventually holding positions as commander of the imperial guard (1543-1546), High Admiral of the Fleet (1546-1551), Governor-General of Rumelia (1551-1555), Third Vizier (1555-1561), Second Vizier (1561-1565) and as Grand Vizier (1565-1579) (for a total of 14 years, 3 months, 17 days) under three Sultans: Suleiman the Magnificent, Selim II, and Murad III.

He is assassinated in 1579, ending a near 15-year rule as de facto ruler of the Ottoman Empire.