Sargon II ( Akkadian Šarru-kên "legitimate king", reigns 722 – 705 BCE) is an Assyrian king.

Sargon II becomes co-regent with Shalmaneser V in 722 BCE, and becomes the sole ruler of the kingdom of Assyria in 722 BCE after the death of Shalmaneser V. It is not clear whether he is the son of Tiglath-Pileser III or a usurper unrelated to the royal family.

In his inscriptions, he styles himself as a new man, rarely referring to his predecessors; however he takes the name Sharru-kinu ("true king"), after Sargon of Akkad — who had founded the first Semitic Empire in the region some 16 centuries earlier.

Sargon is the Biblical form of the name.