Rafael Perestrello (fl.

1514–1517) is a Portuguese explorer and a cousin of Filipa Moniz Perestrello, the wife of the famed explorer Christopher Columbus He is best known for having been the first to land on the southern shores of mainland China in 1516 and 1517 to trade in Guangzhou, after the Portuguese explorer Jorge Álvares landed on Lintin Island within the Pearl River estuary in May 1513.

Rafael also serves as a trader and naval ship captain for the Portuguese in Sumatra and Portuguese-conquered Malacca.

João de Barros (1496–1570) wrote that Rafael Perestrello almost became lost while sailing by the Andaman Islands, but ventured safely through territory that was rumored to be inhabited by native cannibals.