Pope Leo X (December 11, 1475 – December 1, 1521) was Pope from 1513 to his death in 1521.

He is the last non-priest to be elected Pope.

He is known primarily for the sale of indulgences to reconstruct St. Peter's Basilica and his challenging of Martin Luther's 95 Theses.

He is the second son of Lorenzo de' Medici, the most famous ruler of the Florentine Republic, and Clarice Orsini.

His cousin, Giulio di Giuliano de' Medici, will later succeed him as Pope Clement VII (1523–34).