Don Pedro de Ayala (died January 31, 1513) is a sixteenth-century Spanish diplomat employed by Ferdinand II of Aragon and Isabella I of Castile at the courts of James IV of Scotland and Henry VII of England.

His mission to Scotland is concerned with the King's marriage and the international crisis caused by the pretender Perkin Warbeck.

In his later career he supports Catherine of Aragon in England but is involved in a decade of rivalry with the resident Spanish ambassador in London.

Ayala is a Papal prothonotary, Archdeacon of London, and Bishop of the Canary Islands.

Sources in English reveal little of Ayala's background; however, he is from the noble family of the Counts of Fuensalida in Toledo.

He is the son of Pedro Lopez de Ayala, Commendator of Mora and Treze, and Doña Leonor de Ayala.

His contemporary, the historian Polydore Virgil, who may have known him in England, remarks that he was clever, but no scholar