Orophernes Nicephorus is one of the two false sons whom Antiochus imposes upon her husband, Ariarathes IV, king of Cappadocia.

On the birth, however, of a real son, named Mithradates (afterwards Ariarathes V), Orophernes, so that he might not set up pretensions to the throne, is sent away into Ionia.

When Ariarathes V refuses to marry the sister of Demetrius I Soter, king of Syria, the king supports the claims of Orophernes to the crown of Cappadocia.