Muhammad Shaybani Khan, also known as Abul-Fath Shaybani Khan or Shayabak Khan or Shahi Beg Khan (c. 1451 – December 2, 1510), is an Uzbek leader who consolidates various Uzbek tribes and lays the foundations for their ascendance in Transoxiana and the establishment of the Khanate of Bukhara.

He is a descendant of Shiban (or Shayban), the fifth son of Jochi, Genghis Khan's eldest son.