Hajji Mir Wais Khan Hotak, also known as Mir Vais Ghilzai (1673 – November 1715), is an influential tribal chief of the Ghilzai Pashtuns from Kandahar, Afghanistan, who founds the Hotaki dynasty that rules a wide area in Persia and Afghanistan from 1709 to 1738.

After revolting and killing Gurgin Khan in April 1709, he then twice defeats the powerful Safavid Persian armies in southern Afghanistan.

He is widely known as Mirwais Neeka ("Mirwais the grandfather" in the Pashto language).