King Mingyi Nyo had in 1485 founded the First Taungoo Dynasty at Taungoo, far up the Sittaung River south of Inwa, towards the end of the Ava Kingdom in 1510.

Mingyi Nyo's forty-five-year reign has been one of the few stable regimes in Upper Burma in this age.

Toungoo's remote location (nestled between the Bago Yoma mountain range and the Karen Hill country, and cut off from the main Irrawaddy river valley) proves a vital advantage.

It takes effort to march to Toungoo.

The stability of his kingdom had attracted many refugees, and the flow of refugees had accelerated after Ava's fall.

When the Confederation of Shan States, led by Sawlom of Mohnyin, finally defeated Ava in March 1527, Nyo had deliberately devastated the countryside between Ava and Toungoo, filling the wells and breaking down the channels in the hope of making an impassable belt between Toungoo and the Confederation.

The Burmese bureaucracy and population at Ava had largely fled to Toungoo.

This increased manpower will allow Mingyi Nyo’s son Tabinshwehti and his deputy Bayinnaung to initiate an offensive war against larger kingdoms.

Tabinshwehti's improbable victory over Hanthawaddy has its beginnings in Mingyi Nyo's long stable rule.

Mingyi Nyo dies on November 24, 1530, and is succeeded by his fourteen-year-old son Tabinshweti, who rewards his childhood staff by handing out royal titles, and by marrying two of their daughters—Khin Hpone Soe, daughter of Mingyi Swe and sister of Ye Htut, and Khin Myat, daughter of Shin Nita.

He also places his young friends, including Ye Htut, as confidants.

Min Bin at Dhaka on February 8, 1533, receives tribute from local lords of Bengal, and raises a sixteen-year-old princess of Bengal royalty to queen.

He then pays a pilgrimage on March 26, 1533, to Bodh Gaya.

He leaves Dhaka for Mrauk-U on April 13, and on May 14 appoints governors of the newly acquired territories .

According to historians, his control of Bengal beyond Chittagong, where coins bearing his name and styling him sultan are struck, is nominal.

Like Bengal's sultans before him, he has to contend with raids by "Tripuri tribes" from the north throughout his reign, not just on Dhaka but also on Chittagong and Ramu.