Saint Meletius of Antioch (died 381) is a Christian bishop, or Patriarch of Antioch, from 360 until his death.

There are contrasting view about his theological position: on the one hand, he is exiled three times under Arian emperors; on the other, he is strongly opposed by those faithful to the memory of the staunchly pro-Nicene Eustathius of Antioch, whom the synod of Melitene had deposed for his Homousianism (Nicene trinitarianism), which they considered a heresy, and by Saint Athanasius of Alexandria, the firm opponent of Arianism.

One of his last acts is to preside over the First Council of Constantinople in 381.