Martín Fernández de Enciso (c. 1470 – 1528) is a navigator and geographer from Seville, Spain.

He is instrumental in colonizing the Isthmus of Darien.

Fernandez de Enciso founds a village near the Cabo de la Vela with the name Nuestra Señora Santa María de los Remedios del Cabo de la Vela, the first settlement in the Guajira Peninsula.

Due to constant attacks from the indigenous and pirates, the village is moved to present-day Riohacha in 1544.

His Summa de Geografia que trata de todas las partidas e provincias del mundo, published in 1519 in Seville, is the first account in the Spanish language of the discoveries of the New World.