Maria of Antioch (1145–1182) was a Byzantine empress as the wife of the Byzantine Emperor Manuel I Komnenos.

She was the daughter of Constance of Antioch and her first husband Raymond of Poitiers.

Her only son was Alexios II Komnenos, who succeeded Manuel in 1180, and died three years afterwards at the age of 14.

She acted as regent of the Byzantine Empire in 1180-1182.