Manuel I Megas Komnenos (died March 1263) is an Emperor of Trebizond, from 1238 to 1263.

At the time Manuel reignw, the Empire of Trebizond comprises a band of territory stretching along the southern coast of the Black Sea.

Although Michael Panaretos, a fourteenth-century Greek chronicler, calls Manuel "the greatest general and the most fortunate" and states he ruled "virtuously in the eyes of God", the only event he documents for Manuel's reign is a catastrophic fire striking the city of Trebizond in January 1253.

The major events of his reign are known from external sources, most important of which is the recovery of Sinope in 1254, which had been lost to the Sultanate of Rum forty years before.