The work of Piero di Cosimo, a Florentine whose later paintings reflect the influence of Leonardo da Vinci, among others, remains distinguished by a uniquely personal imaginative vision and love of visual incident.

The Myth of Prometheus, a series of five panels painted by Piero, shows Prometheus standing before a life-size statue.

His undated “Fight between the Lapiths and the Centaurs” displays an energetic urgency reminiscent of Luca Signorelli.

He dies in his late fifties.

Vasari gives Piero's date of death as 1521, and this date is still repeated by many sources.

However, contemporary documents reveal that he died of plague on April 12, 1522.

Italian poet and dramatist Luigi Alamanni, a friend of Niccolo Machiavelli, is involved in an unsuccessful conspiracy against Cardinal Giulio de Medici in 1522.

Alamanni flees Florence for France, where he becomes court poet to King Francis.