Louise Florence Pétronille Tardieu d'Esclavelles d'Épinay (March 11, 1726 – April 17, 1783), better known as Mme. d'Épinay,is a French writer, a saloniste and woman of fashion, known on account of her liaisons with Friedrich Melchior, Baron von Grimm, and Jean-Jacques Rousseau, who gives unflattering reports of her in his Confessions, as well as her acquaintanceship with Denis Diderot, Jean le Rond d'Alembert, Baron d'Holbach and other French men of letters during the Enlightenment.

She is also one of many women referenced in Simone de Beauvoir's The Second Sex as an example of noble expansion of women's rights during the eighteenth century.