John II of Anjou (Nancy, August 2, 1424 – December 16, 1470, Barcelona) is Duke of Lorraine from 1453 to his death.

He inheritsthe duchy from his mother, Duchess Isabelle, during the life of his father, Duke René of Anjou, also Duke of Lorraine and titular king of Naples.

As heir-apparent of Naples, he is styled the Duke of Calabria, and spends most of his time engaging in plots for Angevin recovery of Naples.

In 1466, the Catalonians choose his father as King of Aragon, and he is created Prince of Girona, as heir-apparent.

He goes into Catalonia to press the family's claims, but dies, supposedly by poison, in Barcelona.