John Axouch or Axouchos, also transliterated as Axuch (Greek: Ἰωάννης Ἀξούχ or Ἀξοῦχος, flourished circa 1087 – circa 1150) is the commander-in-chief (megas domestikos) of the Byzantine army during the reign of Emperor John II Komnenos (r. 1118–1143), and during the early part of the reign of his son Manuel I Komnenos (r. 1143–1180).

He may also have served as the de facto chief of the civil administration of the Byzantine Empire.