Lady Isabel Neville (September 5, 1451 – December 22, 1476) is the elder daughter of Richard Neville, 16th Earl of Warwick (the Kingmaker of the Wars of the Roses), and Anne de Beauchamp, 16th Countess of Warwick.

She is the wife of George Plantagenet, 1st Duke of Clarence.

She is also the elder sister of Anne Neville, who is Princess of Wales, by her first marriage and Queen consort of England by her second.