Shah Hussain Hotak, son of Mirwais Hotak, is the fifth and final ruler of the Hotaki dynasty.

An ethnic Pashtun (Afghan) from the Ghilzai tribe, he succeeds to the throne after the death of his brother Mahmud Hotak in 1725.

While his cousin Ashraf rules Greater Persia from Isfahan, Hussain rules the Afghanistan region from Kandahar.