Hethum II (also transliterated Hethoum, Hetoum, Het'um, or Hayton from Armenian) (1266 – November 17, 1307) is king of the Armenian Kingdom of Cilicia, ruling from 1289 to 1293, 1295 to 1296 and 1299 to 1303, while Armenia is a subject state of the Mongol Empire.

He abdicates twice in order to take vows in the Franciscan order, while still remaining the power behind the throne as "Grand Baron of Armenia" and later as Regent for his nephew.

He is the son of Leo II of Armenia and Kyranna de Lampron, and is part of the Hethumid dynasty, being the grandson of Hethum I, who had originally submitted Cilicia to the Mongols in 1247.

He is assassinated with his nephew and successor Leo III by the Mongol general Bilarghu, who himself is later executed for this by the Mongol Ilkhan ruler Öljaitü.