Hernando Pizarro y de Vargas (born between 1478 and 1508, died 1578 or 1608) is a Spanish conquistador and one of the Pizarro brothers who rules over Peru.

He ultimately dies in Spain of severely extended age, contrary to his brothers who all suffer a violent fate.

Hernando was born in Trujillo, (Extremadura), Spain, son of Captain Gonzalo Pizarro y Rodríguez de Aguilar (senior) (1446-1522) - who as colonel of infantry served in the Italian campaigns under Gonzalo Fernández de Córdoba, and in Navarre, with some distinction - and wife Isabel de Vargas.