Georges d'Amboise (1460 – May 25, 1510) is a French Roman Catholic cardinal and minister of state.

He belongs to the house of Amboise, a noble family possessed of considerable influence: of his nine brothers, four are bishops.

His father, Pierre d'Amboise, seigneur de Chaumont, is chamberlain to Charles VII and Louis XI and ambassador at Rome.

Georges' eldest brother, Charles, is governor of the Île-de-France, Champagne and Burgundy, and councilor of Louis XI.