Pizarro, Almagro, and Luque, two years after the first very unsuccessful expedition to South America, start the arrangements for a second expedition with permission from Pedrarias Dávila.

The governor, who himself is preparing an expedition north to Nicaragua, is reluctant to permit another expedition, having lost confidence in the outcome of Pizarro's expeditions.

The three associates, however, eventually win his trust and he acquiesces.

Also by this time, a new governor is to arrive and succeed Pedrarias Dávila.

This is Pedro de los Ríos, who had manifested his initial approval of Pizarro's expeditions and will take charge of the post in July 1526 (he will join Pizarro several years later in Peru).

Luque acts as an agent for the financial backer, Judge Gaspar de Espinosa, of the joint expedition by Pizarro and Almagro to Peru in 1526.