Francisco Serrão (died 1521) is a Portuguese explorer and a cousin of Ferdinand Magellan.

His 1512 voyage is the first known European sailing east past Malacca through Indonesia and the Indies.

He becomes a confidante of the Sultan Bayan Sirrullah, the ruler of Ternate, becoming his personal advisor.

He remains in Ternate where he dies around the same time Magellan dies.