Daniele Ricciarelli, a Mannerist painter and sculptor born in Volterra (in today's Tuscany), had initially studied with the Sienese artists Il Sodoma and Baldassare Peruzzi, but he was not well received and left them.
He appears to have accompanied the latter to Rome in 1535, and helped paint the frescoes in the Palazzo Massimo alle Colonne.
He then became an apprentice to Perin del Vaga.
He had helped Perin from 1538 to 1541 with the painting of frescoes in the villa of Cardinal Trivulvives at Salone, in the Massimi chapel in Trinità dei Monti, and the chapel of the crucifixion in San Marcello al Corso.
He was commissioned to paint a frieze in the main salon of the Palazzo Massimo alle Colonne, depicting the life of Fabius Maximus.
In Rome, he also started working in the circle of Michelangelo and befriended him.
Michelangelo has used his influence with Pope Paul III to secure Daniele commissions and the post of superintendent of the works of the Vatican, a position he is to retain until the Pope's death.
Michelangelo has also provided him with sketches on which Daniele bases some of his paintings, especially his series of frescoes in the Orsini chapel in the Trinità dei Monti, the commission for which Daniele had received in December of 1541.
Daniele’s best-known painting is the Descent from the Cross in the Trinità dei Monti (circa 1545), after drawings by Michelangelo; by an excess of praise, this work was at one time grouped with Raphael's Transfiguration and the Last Communion of St. Jerome by Domenichino as the most famous pictures in Rome.