Comentiolus (died 602) is a prominent Eastern Roman (Byzantine) general at the close of the 6th century during the reign of Emperor Maurice (r. 582–602).

He plays a major role in Maurice's Balkan campaigns, and fights also in the East against the Sassanid Persians.

Comentiolus is ultimately executed in 602 after the Byzantine army rebels against Maurice and Emperor Phocas (r. 602–610) usurps the throne.