Bairam Khan also Bayram Khan (died 1561) is an important military commander, later commander-in-chief of the Mughal army, a powerful statesman and regent at the court of the Mughal emperors Humayun and Akbar.

He is also guardian, chief mentor, advisor, teacher and the most trusted ally of Humayun.

Humayun honors him as Khan-i-Khanan, which means king of kings. Bairam is originally called Bairam "Beg" but later becomes honored as 'Kha' or Khan.