Anne de Pisseleu d'Heilly (1508 – 1580), Duchess of Étampes, is the mistress of Francis I of France.

She is a daughter of Adrien de Pisseleu, seigneur d'Heilly, a nobleman of Picardy,Genealogy who, with the rise of his daughter at court, is made seigneur of Meudon, master of waters and forests of Île de France, of Champagne and of Brie.