Amenhotep II (sometimes read as Amenophis II and meaning Amun is Satisfied) is the seventh Pharaoh of the 18th dynasty of Egypt.

Amenhotep inherits a vast kingdom from his father Thutmose III, and holds it by means of a few military campaigns in Syria; however, he fights much less than his father, and his reign sees the effective cessation of hostilities between Egypt and Mitanni, the major kingdoms vying for power in Syria.

His reign is usually dated from 1427 to 1400 BCE.