Amenhotep I, from Ancient Egyptian "jmn-ḥtp" or "yamānuḥātap" meaning "Amun is satisfied" or Amenophis I, from Ancient Greek Ἀμένωφις, additionally King Zeserkere (transliteration: Ḏśr-k-R), is the second Pharaoh of the Eighteenth dynasty of Egypt.

His reign is generally dated from 1526 to 1506 BCE.

He is a son of Ahmose I and Ahmose-Nefertari, but had at least two elder brothers, Ahmose-ankh and Ahmose Sapair, and was not expected to inherit the throne.

However, sometime in the eight years between Ahmose I's seventeenth regnal year and his death, his heir apparent died and Amenhotep became crown prince.

He then accedes to the throne and rules for about twenty-one years.

Although his reign is poorly documented, it is possible to piece together a basic history from available evidence.

He inherits the kingdom formed by his father's military conquests and maintains dominance over Nubia and the Nile Delta but probably does not attempt to maintain Egyptian power in the Levant.

He continues the rebuilding of temples in Upper Egypt and revolutionizes mortuary complex design by separating his tomb from his mortuary temple, setting a trend in royal funerary monuments that will persist throughout the New Kingdom.

After his death, he is deified as a patron god of Deir el-Medina.