Alexios Apokaukos (died 1345) is a leading East Roman (Byzantine) statesman and high-ranking military officer (megas doux) during the reigns of emperors Andronikos III Palaiologos (r. 1328–1341) and John V Palaiologos (r. 1341–1357).

Although he owes his rise to high state offices to the patronage of John VI Kantakouzenos (r. 1347–1354), he becomes, together with Patriarch John XIV Kalekas, one of the leaders of the faction supporting Emperor John V in the civil war of 1341–1347 against his one-time benefactor.

Apokaukos dies when he is lynched by political prisoners during an inspection of a new prison.