Amir Akbar Khan (1816–1845), born as Mohammad Akbar Khan) and famously known as Wazir Akbar Khan, is an Afghan prince, general, and emir for about three years until his death.

He is militarily active in the First Anglo-Afghan War, which lasts from 1839 to 1842.

He is prominent for his leadership of the national party in Kabul from 1841 to 1842, and his pursuit of the retreating British-led Indian army from Kabul to Gandamak near Jalalabad in 1842.

Previously, in the 1837 Battle of Jamrud, he had killed Sikh General Hari Singh Nalwa while attempting to regain Afghanistan's second capital, Peshawar, from the invading Sikh army of Punjab.